Management of alcohol use disorder: a gastroenterology and hepatology-focused perspective.

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Tác giả: Juan Pablo Arab, Gustavo Ayares, Ramon Bataller, Luis Antonio Díaz, José Miguel Fuentealba, Patrick S Kamath, Daniel König, Lorenzo Leggio, Valeria Vázquez, Sabine Weber, Gerald Scott Winder

Ngôn ngữ: eng

Ký hiệu phân loại: 615.7828 Pharmacokinetics

Thông tin xuất bản: Netherlands : The lancet. Gastroenterology & hepatology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 164456

Alcohol use disorder is a prevalent and major but preventable cause of morbidity and mortality worldwide, causing several important health consequences, including chronic liver disease. Despite its substantial effects, most clinicians do not adequately assess alcohol intake in clinical practice, and there are several barriers to providing integrated management to patients with alcohol use disorder. Standardised questionnaires, such as the Alcohol Use Identification Test (AUDIT), can facilitate the identification of individuals at risk of alcohol use disorder, and alcohol biomarkers such as phosphatidylethanol aid in quantifying levels of alcohol consumption. Non-pharmacological interventions-including brief interventions, twelve-step facilitation, motivational enhancement therapy, contingency management, and cognitive behavioural therapy-are effective for patients with alcohol use disorder, regardless of the presence of advanced liver disease. Pharmacological treatments should be considered according to the severity of liver disease and other comorbidities, safety profile, and local availability. The management of patients with alcohol use disorder and associated liver disease should ideally be performed in the setting of integrated multidisciplinary teams.
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