Discovery of a novel microtubule destabilizing agent targeting the colchicine site based on molecular docking.

• Tác giả: Jiangying Cai, Hongwei Gao, Miao He, Yingying Wang, Yubin Wang, Yaxin Xu, Chongge You, Hui Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 171.8 Systems based on altruism
• Thông tin xuất bản: England : Biochemical pharmacology , 2025
• Bộ sưu tập: NCBI
• ID: 164720

Tóm tắt

Although a number of microtubule-targeting agents have been used in tumour therapy, their resistance and drug toxicity pose clinical challenges. Microtubule destabilizing agents (MDAs) targeting the colchicine site were found to have the advantage of being able to overcome drug resistance. In our previous studies, we identified a novel MDA from the compound database based on virtual screening methods. Its chemical formula is C