The development of sustainable bamboo has received increasing attention owing to its excellent strength-to-weight ratio and environmental characteristics. However, the defects of mechanical properties, dimensional stability, and antibacterial activity of natural bamboo severely limit its practical application. Inspired by the catechol chemistry and ionic feature of mussels, a strong, tough, and antibacterial bamboo material is designed and developed by incorporating deep eutectic solvent (DES) functionalized boron nitride (BN) hybrids. Specifically, the functional DES is prepared from catechol gallic acid and cationic (meth)acrylic ammonium salts. Subsequently, efficient in-situ deposition of DES@BN hybrids on the bamboo is achieved through vacuum impregnation, photopolymerization technology, and temperature-assisted compression densification. The phenolic DES polymer not only provides a multiple chemical reaction platform for BN sheets, but also enhances the interfacial binding between BN and bamboo fibers through supramolecular interactions and catechol chemistry. The tensile and flexural strengths of the modified bamboo increase significantly to 236.8 and 218.4 MPa, which are 100.8 % and 61.7 % higher than the original sample. Additionally, the fabricated bamboo composites exhibit significantly enhanced dimensional stability and excellent antibacterial activity. This innovative and versatile strategy of fabricating high-performance bamboo shows great potential for application in sustainable building structures, decorative materials, and furniture production.