The Role of Mitochondrial Dysfunction and Calcium Dysregulation in 2C-I and 25I-NBOMe-Induced Neurotoxicity.

• Tác giả: Daniel José Barbosa, Ana Borer, Fernanda Borges, Fernando Cagide, Daniel Chavarria, Carlos Fernandes, Eva Gil-Martins, Fernando Remião, Renata Silva
• Ngôn ngữ: eng
• Ký hiệu phân loại: 271.6 *Passionists and Redemptorists
• Thông tin xuất bản: Ireland : Chemico-biological interactions , 2025
• Bộ sưu tập: NCBI
• ID: 165005

Tóm tắt

New psychoactive substances (NPS) are designed to evade legal regulation while mimicking the effects of classic illicit drugs such as 3,4-methylenedioxymethamphetamine (MDMA). This category includes phenethylamine derivatives, such as the psychedelic 2C and NBOMe drugs. Given the lack of data regarding the toxicological profile of these substances, the goal of this study was to evaluate the neurotoxicity of 2C-I and 25I-NBOMe and explore their neurotoxic pathways. Lower EC