Design, synthesis and biological evaluation of Streptazolin analogs as anti-inflammatory agents.

• Tác giả: Lingling Ding, Shanqin Huang, Bo Jiang, Peng Jiang, Zhuang Li, Shan Lu, Ke Ma, Di Mao, Xinhang Su, Ying Xu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 004.338 Systems analysis and design, computer architecture, performance evaluation of real-time computers
• Thông tin xuất bản: England : Bioorganic & medicinal chemistry letters , 2025
• Bộ sưu tập: NCBI
• ID: 165041

Tóm tắt

A plant endophytic actinomycete Streptomyces sp. JS39-4 was isolated from the root of water spinach (Ipomoea aquatica Forsk.). Its main secondary metabolite streptazolin (1) was purified in a high yield under the optimized cultural condition. Sixteen analogs of streptazolin with modification at C-5 were synthesized. Among them, compound 2e exhibits the most potent anti-inflammatory activity in LPS-induced RAW 264.7 mouse macrophages. The current research provides the first report on the anti-inflammatory activity of streptazolin analogs.