TREM2 depletion in pancreatic cancer elicits pathogenic inflammation and accelerates tumor progression via enriching IL-1β

• Tác giả: Yang Chen, Anirban Maitra, Xinlei Sun, Hua Wang, Huamin Wang, Ignacio I Wistuba, Daowei Yang
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Gastroenterology , 2025
• Bộ sưu tập: NCBI
• ID: 165180

Tóm tắt

 BACKGROUND & AIMS: Pancreatic ductal adenocarcinoma (PDAC) has a complex tumor microenvironment enriched with tumor-associated macrophages. Triggering receptor expressed on myeloid cells 2 (TREM2) is highly expressed by a subset of macrophages in PDAC. However, the functional role of TREM2 in PDAC progression remains elusive. METHODS: We generated a novel transgenic mouse model (KPPC
 Trem2 RESULTS: Unexpectedly, genetic depletion of TREM2 significantly accelerated spontaneous PDAC progression and shortened the survival of KPPC
 Trem2 CONCLUSIONS: TREM2 depletion accelerates tumor progression by enhancing pro-inflammatory macrophages and IL-1β-mediated pathogenic inflammation in PDAC. The accelerated tumor progression by TREM2 depletion can be reversed by blocking IL-1β-associated pathogenic inflammation.