sa-mRNA influenza vaccine raises a higher and more durable immune response than mRNA vaccine in preclinical models.

• Tác giả: Cheng Chang, Annette Ferrari, Giuseppe Palladino, Harsh Patel, Daniel Petkov, Evan Rossignol, Tina Scalzo, Yingxia Wen, Howard Xu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.0795 Diseases
• Thông tin xuất bản: Netherlands : Vaccine , 2025
• Bộ sưu tập: NCBI
• ID: 165521

Tóm tắt

mRNA-based vaccines can be rapidly manufactured and have been demonstrated clinically to raise robust immune responses to COVID-19 and protect against severe COVID-19 disease. The clinical immunogenicity and efficacy of self-amplifying mRNA (sa-mRNA) vaccines have also been demonstrated, along with a longer duration of action than mRNA vaccines. However, a detailed understanding of differences between sa-mRNA and conventional mRNA vaccines with modified bases is lacking. Compared with a N