Design, Synthesis, and Characterization of 1-(Anthracen-9-ylmethyl)-1,5,9-triazacyclododecane (Ant-[12]aneN3) and Its DNA Photocleavage Activity.

• Tác giả: Mikako Fujita, Yoshimi Ichimaru, Wanchun Jin, Koichi Kato, Masaaki Kurihara, Hiromasa Kurosaki, Masami Otsuka, Takayuki Sakamoto, Yoshihiro Yamaguchi
• Ngôn ngữ: eng
• Ký hiệu phân loại: 272.3 Persecutions of Waldenses and Albigenses
• Thông tin xuất bản: Japan : Chemical & pharmaceutical bulletin , 2025
• Bộ sưu tập: NCBI
• ID: 166204

Tóm tắt

Here, a DNA cleavage reagent (1-(anthracen-9-ylmethyl)-1,5,9-triazacyclododecane = Ant-[12]aneN3) was designed and synthesized, and its DNA photocleavage activity under UV irradiation at λ = 365 nm was evaluated. Ant-[12]aneN3 is a molecule containing anthracene as the photosensitizer and [12]aneN3 ( = 1,5,9-triazacyclododecane) as the DNA-interacting component. The cyclic polyamine [12]aneN3 could coordinate with zinc ions (Zn