INTRODUCTION: Care for people living with dementia is both important and complex, and there is evidence of large regional variations in the quality of care. This study protocol describes design, methods and objectives of an investigation of regional variations in the utilisation, the quality and the costs of care for people living with dementia in Germany. METHODS AND ANALYSIS: An exploratory, naturalistic, mixed-methods study is being conducted with three modules: ETHICS AND DISSEMINATION: The study is overseen by the German Alzheimer's Association. The study's ethics and data protection plan was approved by the data and ethics committee of the leading university, Brandenburg Medical School Theodor Fontane (reference number: 152092023-BO-E) as well as the data committee of the three participating health insurances. Dissemination plans include dissemination of our main results to the general public, people affected, the scientific community and funding-, policy- and decision makers. Study outcomes and conclusions will be published on our own and the funder's websites, through presentations at conferences and in scientific journals. The funder ensures dissemination of main study results and recommendations for action to relevant organisations and institutions. Publication of the study's main results is planned within 6 months of the study's conclusion. TRIAL REGISTRATION NUMBER: DRKS00031944 (https://trialsearch.who.int/Trial2.aspx?TrialID=DRKS00031944).