The mission statement (MS) is the most used organizational strategic planning tool worldwide. The relationship between an MS and an organizations financial performance has been shown to be significantly positive, albeit small. However, an MSs relationship to the macroeconomic environment and to organizational innovation has not been investigated. We implemented a Structural Equation Modeling using the SCImago Institutional Ranking (SIR) as a global baseline sample and assessment of organizational research and innovation (RandI), an automated MS content analysis, and the Economic Complexity Index (ECI) as a comprehensive macroeconomic environment measure. We found that the median performance of organizations that do not report an MS is significantly higher than that of reporting organizations, and that a path-dependence driven by the State's long-term view and investment is a better explanatory variable for organizational RandI performance than the MS construct or the intermediate-term macroeconomic environment.