PDE4B Modulates Phosphorylation of p65 (Ser468) via cAMP/PKA in Acute Lung Injury.

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Tác giả: Rana Dhar, Zhengqiang Hu, Jie Ji, Yajun Li, Zigang Li, Shunde Song, Huifang Tang, Xuefeng Wang, Chunguang Yan, Zhewen Zhang, Xuyang Zheng

Ngôn ngữ: eng

Ký hiệu phân loại: 305.568 +Alienated and excluded classes

Thông tin xuất bản: United States : Lung , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 167271

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AIM: The important role of phosphodiesterase 4B (PDE4B) inhibition on lipopolysaccharide (LPS)-induced ALI has been reported. However, the corresponding mechanisms remain unclear. In the present study, the relationship between PDE4B and phosphorylation of p65 (Ser468) in LPS-induced injury by in vivo and in vitro models was investigated. METHODS AND RESULTS: pde4b CONCLUSIONS: PDE4B plays a critical role in orchestrating LPS-induced acute lung inflammation by cAMP/PKA axis-mediated phosphorylation of p65.

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