Protein and DNA Conformational Changes Contribute to Specificity of Cre Recombinase.

• Tác giả: Mark P Foster, Megan E Judson, Jonathan S Montgomery
• Ngôn ngữ: eng
• Ký hiệu phân loại: 364.086949 Criminology
• Thông tin xuất bản: United States : Biochemistry , 2025
• Bộ sưu tập: NCBI
• ID: 167504

Tóm tắt

Cre, a conservative site-specific tyrosine recombinase, is a powerful gene editing tool in the laboratory. Expanded applications in human health are hindered by a lack of understanding of the mechanism by which Cre selectively binds and recombines its cognate