This paper proposes a new method of inference in high-dimensional regression models and high-dimensional IV regression models. Estimation is based on a combined use of the orthogonal greedy algorithm, high-dimensional Akaike information criterion, and double/debiased machine learning. The method of inference for any low-dimensional subvector of high-dimensional parameters is based on a root-$N$ asymptotic normality, which is shown to hold without requiring the exact sparsity condition or the $L^p$ sparsity condition. Simulation studies demonstrate superior finite-sample performance of this proposed method over those based on the LASSO or the random forest, especially under less sparse models. We illustrate an application to production analysis with a panel of Chilean firms.