Effect of erythropoiesis-stimulating agents on malignant neoplasms: FAERS database and mendelian randomization.

• Tác giả: Cuilv Liang, Peihong Wang, Qiaohong Wang, Yin Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 627.12 Rivers and streams
• Thông tin xuất bản: England : Expert review of hematology , 2025
• Bộ sưu tập: NCBI
• ID: 167747

Tóm tắt

BACKGROUND: The relationship between erythropoiesis-stimulating agents (ESAs) and malignant neoplasms (MNs) has been controversial in previous studies. Our study aimed to explore the correlation between ESAs and MNs. RESEARCH DESIGN AND METHODS: Drug-target Mendelian randomization (MR) analyses were conducted to evaluate the causal associations of ESAs for 12 classifications of MNs. Meanwhile, a pharmacovigilance study was performed by extracting adverse events (AEs) in the FDA Adverse Event Reporting System (FAERS) database to validate and complement our findings. MR analysis revealed negative association of ESAs with MN of ovary ( CONCLUSION: ESAs were causally correlated with many types of MNs. More attention needs to be paid to the use of ESAs in these tumors.