OBJECTIVE: To explore the potential of combining natural herbs like chamomile and saffron for the management of anxiety and depression. METHODS: A rodent model of Major Depressive Disorder (MDD) and anxiety, secondary to streptozotocin-induced diabetes mellitus was made. A total of 6 rat groups were chosen
healthy and diseased controls
and diseased test groups of fluoxetine, saffron, chamomile, and combined saffron and chamomile treated ( RESULTS: The combined herbal treatment group showed significantly better ( CONCLUSION: This study shows that in comparison to treatment with a SSRI, and individual herbs, the combination of chamomile and saffron showed overall improved outcomes.