Benchmarking broad-spectrum antibiotic use in older adult pneumonia inpatients: a risk-adjusted smoothed observed-to-expected ratio approach.

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Tác giả: Kiyohide Fushimi, Yuichi Imanaka, Abbas Khatoun, Susumu Kunisawa, Noriko Sasaki

Ngôn ngữ: eng

Ký hiệu phân loại: 636.0885 Animal husbandry

Thông tin xuất bản: United States : Infection control and hospital epidemiology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 168289

OBJECTIVE: Antimicrobial resistance is increased by antibiotic overuse, so it's crucial for stewardship programs to monitor and control their use. Pneumonia, particularly prevalent among older adults in Japan, is requiring higher rates of medical treatment. This study aimed to develop an improved method for benchmarking broad-spectrum antibiotic use in the empiric treatment of pneumonia in older adult inpatients by applying the "smoothed" observed-to-expected (O/E) ratio which adjusts for hospital-level variations and minimizes the effect of extreme values. METHODS: Using nationwide data from the Diagnosis Procedure Combination research group, pneumonia patients between April 1 RESULTS: A total of 244,747 patients from 958 hospitals were included, with a mean age of 81 (±8.30) years. The proportion of broad-spectrum antibiotic use was 35.3% (n = 86,316). The prediction model showed a C-statistic of 0.722. There was a noticeable variation in the O/E ratio among hospitals with values ranging from 0.13 (95% CI: 0.09-0.20) to 2.81 (95% CI: 2.64-2.97). CONCLUSIONS: Using a risk-adjusted smoothed O/E ratio, we assessed the use of broad-spectrum antibiotics across hospitals, identifying those with high O/E ratios that may indicate a need for improvement.
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