Temperature and steric hindrance-regulated selective synthesis of ketamine derivatives and 2-aryl-cycloketone-1-carboxamides

• Tác giả: Penghui Li, Hongshuang Wang, Xiaohui Wang, Haojiang Zhai
• Ngôn ngữ: eng
• Ký hiệu phân loại: 936 Europe north and west of Italian Peninsula to ca. 499
• Thông tin xuất bản: England : Organic & biomolecular chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 168428

Tóm tắt

A selective temperature and steric hindrance-regulated method for nucleophilic substitution or Favorskii rearrangement reactions of 2-aryl-2-bromo-cycloketones with aliphatic amines has been developed to prepare ketamine derivatives and 2-aryl-cycloketone-1-carboxamides. In the presence of secondary amines or