Anterior Cingulate Cortex-Anterior Insular Cortex Circuit Mediates Hyperalgesia in Adolescent Mice Experiencing Early Life Stress.

• Tác giả: Zhaoyi Chen, Jinxiang Jiang, Meng Li, Kefang Liu, Cheng Long, Chunyan Wang, Mingyu Xu, Lu Yu, Jingquan Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 693.83 Insulated construction
• Thông tin xuất bản: United States : ACS chemical neuroscience , 2025
• Bộ sưu tập: NCBI
• ID: 169939

Tóm tắt

Understanding neurobiological mechanisms underlying changes in behavior and neural activity caused by early life stress (ELS) is essential for improving these adverse outcomes in individuals. ELS incited by exposure to maternal separation (MS) can be defined as a form of social pain, but little is known about the neural mechanism in adolescents with ELS-induced pain sensitization. Employing an MS-induced ELS paradigm in mice, we reported here that both male and female MS mice aged 1-2 months exhibited mechanical and thermal hyperalgesia using paw-withdrawal and hot/cold plate tests. The increased high gamma (γ