Marjolin ulcers (MUs) are a rare complication of chronically inflamed wounds and scars, with the most common histology being squamous cell carcinoma. MUs have high rates of metastasis and recurrence and a poor prognosis. Due to their aggressive nature, such cutaneous growths require radical excision and subsequent grafting. In large MUs, the use of a multi-stage approach to reconstruction provides better wound healing and graft recipient sites. An additional modality to further the results of the reconstructive approach includes the use of an esterified hyaluronic acid matrix (eHAM) prior to the placement of split-thickness skin grafts. eHAM, frequently used in wounds and deep burns, provides a scaffold for granulation tissue formation thus furthering the strength of graft recipient sites. We present a case of a large MU at the site of a long-standing burn scar that was excised with clear margins and reconstructed with stage skin grafting using eHAM.