INTRODUCTION: The mortality of a disease alludes to the number of deaths caused by that disease within a specific population and timeframe. Urban-rural disparity indicates the differences in quality of life, access to healthcare and services, and economic opportunities between urban and rural areas. Thus, the study aims to evaluate the disparity in mortality rates between the urban versus rural areas for influenza and pneumonia over a 22-year period. METHODS: A retrospective study was conducted on 25 RESULTS: The absolute mortality in rural areas (511,454 deaths
19.3%) is approximately four times lower than urban areas (2,002,659 deaths
79.7%).The trend in mortality rate per 100,000 has gradually decreased over the years. The mortality rate per 100,000 population based on age, gender and race stratification is significantly higher in rural areas compared to the urban areas. CONCLUSION: This study highlights the significant disparities in urban versus rural mortality for patients with influenza and pneumonia, particularly in the 85+ years age group, female gender, and White American race.