Human immunodeficiency virus (HIV) is a virus that targets and destroys a cluster of differentiation 4 (CD4) cells. When left untreated, HIV can lead to acquired immunodeficiency syndrome (AIDS), which the presence of AIDS-defining diseases can characterize. Here, the authors report the diagnostic and therapeutic approach to a case of a 56-year-old male living with HIV who presented to the emergency department with dyspnea and fever. Chest CT revealed ground-glass opacities, consistent with