Syphilis is a highly contagious infectious disease primarily transmitted through sexual contact, caused by Treponema pallidum, an anaerobic gram-negative bacterium. Oral manifestations are significant, with the oral cavity often being the first site to exhibit symptoms. This study aims to present the clinical manifestations of oral syphilis through a six cases diagnosed in a dental setting. The results reveal that oral syphilis lesions predominantly affect areas such as the tongue, gingiva, and palates, presenting as mucous plaques, ulcerations, and erythematous regions. Painful oral sores and cervical lymphadenopathy were common, with symptoms varying in duration from 3 weeks to 3 months. All cases were classified as secondary syphilis and were confirmed through serological tests.