The emerging role and therapeutical implications of ferroptosis in wound healing.

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Tác giả: Zhiyang Chen, Qian Hu, Zhenyu Ju, Feng Xiao, Shenghao Xie, Yanan Zhao

Ngôn ngữ: eng

Ký hiệu phân loại: 070.484 Foreign-language and nondominant ethnic and national groups

Thông tin xuất bản: England : Burns & trauma , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 171191

Wound healing is a complex biological process involving multiple steps, including hemostasis, inflammation, proliferation, and remodeling. A novel form of regulated cell death, ferroptosis, has garnered attention because of its involvement in these processes. Ferroptosis is characterized by the accumulation of lipid peroxides and is tightly regulated by lipid metabolism, iron metabolism, and the lipid-peroxide repair network, all of which exert a significant influence on wound healing. This review highlights the current findings and emerging concepts regarding the multifaceted roles of ferroptosis throughout the stages of normal and chronic wound healing. Additionally, the potential of targeted interventions aimed at modulating ferroptosis to improve wound-healing outcomes is discussed.
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