BACKGROUND: Accurately predicting pathological complete response (pCR) to neoadjuvant chemotherapy (NACT) in breast cancer remains a clinical challenge. Current imaging-based models are limited in their ability to integrate key metabolic parameters to enhance prediction accuracy. This study aimed to develop and validate a nomogram using METHODS: This retrospective cohort study enrolled 95 breast cancer (BC) patients who underwent RESULTS: Relative to the non-pCR cohort, the pCR group exhibited smaller tumor diameters, lower Ki-67 expression, fewer lymph node metastases, and higher proportions of HER2+ molecular subtype (P<
0.05). Pretreatment SUV