A comprehensive analysis of the uterine microbiome in endometrial cancer patients - identification of

 0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Aleksandra Bolanowska, Anna Drozdzowska, Tomasz Kluz, Aleksandra Kowalczyk, Olga Kuźmycz, Jakub Lach, Paweł Stączek, Wiktoria Wierzbińska

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: Switzerland : Frontiers in cellular and infection microbiology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 171909

INTRODUCTION: Endometrial cancer (EC) is a significant gynecological malignancy with increasing incidence worldwide. Emerging evidence highlights the role of the uterine microbiome in the pathogenesis of EC. This study aims to characterize the uterine microbiome in EC patients and identify potential microbial biomarkers, with a focus on METHODS: The endocervical canal swabs from patients with EC (n=16) and non-cancerous patients (EM, n=13) were collected. The V3-V4 region of the 16S rRNA gene was sequenced using the Illumina platform. Bioinformatic analyses were performed with QIIME2, and statistical comparisons were conducted to assess differences in microbial composition and diversity. RESULTS: The α-diversity metrics, including Shannon entropy and observed amplicon sequence variants (ASVs), revealed significantly higher microbial diversity in EC samples compared to EM. DISCUSSION: The study provides evidence of distinct microbial signatures in EC, with
Tạo bộ sưu tập với mã QR

THƯ VIỆN - TRƯỜNG ĐẠI HỌC CÔNG NGHỆ TP.HCM

ĐT: (028) 36225755 | Email: tt.thuvien@hutech.edu.vn

Copyright @2024 THƯ VIỆN HUTECH