Pyrvinium Pamoate Synergizes with Azoles in vitro and in vivo to Exert Antifungal Efficacy Against

• Tác giả: Jing Hu, Gaolian Li, Jingwen Tan, Heng Zhang, Jinqing Zhang, Yizheng Zhou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 627.12 Rivers and streams
• Thông tin xuất bản: New Zealand : Infection and drug resistance , 2025
• Bộ sưu tập: NCBI
• ID: 171957

Tóm tắt

 INTRODUCTION: Treating infections caused by azole-resistant MATERIALS AND METHODS: A total of 21 clinical RESULTS: When used to treat these different fungal isolates in vitro, the single-agent efficacy of PP was relatively poor, with minimum inhibitory concentration values ranging from 2 μg/mL - >
 32 μg/mL. However, PP and azoles exhibited synergistic activity against the majority of analyzed CONCLUSION: Combining PP with azoles represents a promising approach to effectively disrupting the growth of azole-resistant