The Sierra Madre Oriental (SMO) in Mexico is a complex, unexplored geological area with multiple habitats and unique physical, chemical, and biological features. A bioactive-guided study of the organic extract from a solid-state fermentation culture from a taxonomically unidentified fungus isolated from submerged wood in the waterfall "El Caracol", Nuevo Leon, at the SMO, led to the identification of three new cyclodepsipeptides (