OBJECTIVES: To investigate the efficacy of biofeedback electrical stimulation combined with early intensive rehabilitation training on cerebral blood circulation, neurological function recovery, motor performance, and self-care abilities in stroke patients. METHODS: A retrospective analysis was conducted on 120 stroke patients admitted to the Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University from September 2021 to October 2023. Patients were divided into an observation group (n=60) receiving the combined treatment and a control group (n=60) receiving standard rehabilitation. Efficacy was evaluated through the analysis of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) levels, as well as assessments of several clinical variables, including Peak Systolic Velocity (PSV), Mean Velocity (Vm), Resistance Index (RI), Fugl-Meyer Assessment (FMA), Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Berg Balance Scale (BBS), National Institutes of Health Stroke Scale (NIHSS), Modified Barthel Index (MBI), and Stroke-Specific Quality of Life Scale (SS-QOL). Measurements were taken before treatment and upon completion. RESULTS: The findings revealed that the combination of electrical stimulation with early rehabilitation exercises significantly improved cerebral blood flow in stroke patients. This approach accelerated the recovery of neurological functions, enhanced motor skills, and improved self-care capabilities among participants. The results demonstrated substantial treatment benefits alongside a favorable safety profile. CONCLUSIONS: The integration of biofeedback electrical stimulation with intensive rehabilitation exercises significantly enhances neurological and motor function recovery in stroke patients while promoting better self-care skills, all within a safe treatment framework. This approach warrants further clinical research and potential implementation.