Insulin autoantibodies, D-dimer and microalbuminuria: A cross-sectional, case-control study of type 2 diabetes.

• Tác giả: Hong Chen, Xiao-Mu Li, Zhi-Qiang Lu, Fei Yao, Peng Yu, Lin-Shan Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 553.453 Tin
• Thông tin xuất bản: United States : World journal of diabetes , 2025
• Bộ sưu tập: NCBI
• ID: 172240

Tóm tắt

BACKGROUND: Type 2 diabetes mellitus (T2DM) often leads to vascular complications, such as albuminuria. The role of insulin autoantibodies (IAA) and their interaction with D-dimer in this context remains unclear. AIM: To investigate the characteristics of IAA and its effect on albuminuria in T2DM patients. METHODS: We retrospectively analyzed clinical data from 115 T2DM patients with positive IAA induced by exogenous insulin, and 115 age- and sex-matched IAA-negative T2DM patients as controls. Propensity scores were calculated using multivariate logistic regression. Key variables were selected using the least absolute shrinkage and selection operator (LASSO) algorithm. We constructed a prediction model and analyzed the association between IAA and albuminuria based on demographic and laboratory parameters. RESULTS: The IAA-positive group had significantly higher D-dimer levels [0.30 (0.19-0.55) mg/L CONCLUSION: D-dimer elevation is an independent risk factor for abnormal albuminuria and interacts with IAA in the development of abnormal albuminuria in T2DM patients.