BACKGROUND: Numerous epidemiological studies have found that pesticide exposure is associated with the incidence of type 2 diabetes (T2D)
however, the underlying mechanisms remain unknown. DNA methylation may play a role in this process. AIM: To identify the genes associated with pesticide exposure and T2D by reviewing the current literature. METHODS: We systematically searched PubMed and Embase for relevant studies that examined the association between pesticide exposure and DNA methylation, and studies on DNA methylation and T2D through January 15, 2024. RESULTS: We identified six genes ( CONCLUSION: DNA methylation of specific genes may play a vital role in the association between pesticide exposure and T2D.