Monoterpenes as potential antifungal molecules against

• Tác giả: Saiema Ahmedi, Khalid Umar Fakhri, Nikhat Manzoor, Prerna Pathak, Nafis Raj
• Ngôn ngữ: eng
• Ký hiệu phân loại: 627.12 Rivers and streams
• Thông tin xuất bản: England : Journal of biomolecular structure & dynamics , 2025
• Bộ sưu tập: NCBI
• ID: 173184

Tóm tắt

Azoles are the frequently used antifungal drugs that target the enzyme lanosterol 14 α-demethylase (erg11p). This enzyme plays a vital role in ergosterol biosynthesis and hence maintainenance of cell membrane fluidity and integrity. The emergence of resistance to azoles and their fungistatic nature against several fungal pathogens is the major challenge to combat invasive candidiasis. Therefore, there is an urgent need to discover new antifungals with better efficacy. This study targets erg11 protein using