Benzothiazole derivatives as p53-MDM2 inhibitors:

• Tác giả: Abhimanyu Awasthi, Sheshagiri R Dixit, Sudeep D Ghate, Udaya Kumar D, Shridhar Deshpande N, B C Revanasiddappa, Shivakumar
• Ngôn ngữ: eng
• Ký hiệu phân loại: 332.6457 Investment
• Thông tin xuất bản: England : Journal of biomolecular structure & dynamics , 2025
• Bộ sưu tập: NCBI
• ID: 173192

Tóm tắt

Breast cancer stands as the most prevalent malignancy among the female populace. One of the pivotal domains in the therapeutic landscape of breast cancer revolves around the precise targeting of the p53-MDM2 inhibitory pathway. The advent of p53-MDM2 inhibition in the context of developing treatments for breast cancer marks a significant stride. In the quest for enhancing the efficacy of p53-MDM2 inhibition against breast cancer, a new series of benzothiazole compounds (B1-B30) was designed through