T6496 targeting EGFR mediated by T790M or C797S mutant: machine learning, virtual screening and bioactivity evaluation study.

• Tác giả: Dang Fan, Xiaoling Huang, Wei Ruan, Yuanbiao Tu, Linxiao Wang, Pengwu Zheng, Wufu Zhu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 363.232 Patrol and surveillance
• Thông tin xuất bản: England : Journal of biomolecular structure & dynamics , 2025
• Bộ sưu tập: NCBI
• ID: 173221

Tóm tắt

Acquired resistance to EGFR is a major impediment in lung cancer treatment, highlighting the urgent need to discover novel compounds to overcome EGFR drug resistance. In this study, we utilized in silico methods and bioactivity evaluation for drug discovery to identify novel active anticancer agents targeting EGFR