Mechanisms of Anti-PD Therapy Resistance in Digestive System Neoplasms.

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Tác giả: Xiangyan Jiang, Yong Ma, Huiguo Qing, Yuxia Wu, Zongrui Xing, Zeyuan Yu

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: United Arab Emirates : Recent patents on anti-cancer drug discovery , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 173380

Digestive system neoplasms are highly heterogeneous and exhibit complex resistance mechanisms that render anti-programmed cell death protein (PD) therapies poorly effective. The tumor microenvironment (TME) plays a pivotal role in tumor development, apart from supplying energy for tumor proliferation and impeding the body's anti-tumor immune response, the TME actively facilitates tumor progression and immune escape via diverse pathways, which include the modulation of heritable gene expression alterations and the intricate interplay with the gut microbiota. In this review, we aim to elucidate the mechanisms underlying drug resistance in digestive tumors, focusing on immune-mediated resistance, microbial crosstalk, metabolism, and epigenetics. We will highlight the unique characteristics of each digestive tumor and emphasize the significance of the tumor immune microenvironment (TIME). Furthermore, we will discuss the current therapeutic strategies that hold promise for combination with cancer immune normalization therapies. This review aims to provide a thorough understanding of the resistance mechanisms in digestive tumors and offer insights into potential therapeutic interventions.
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