BACKGROUND: Nitroaromatic compounds are important scaffolds used for the synthesis of a variety of compounds, such as explosives, herbicides, dyes, perfumes and pharmaceuticals. Bismuth nitrate pentahydrate is a widely used reagent in organic synthesis
however, its utility as a nitrating agent for anilines is underexplored. OBJECTIVE: The aim of this work is to propose and find the proper reaction conditions of an alternative nitrating agent constituted by a mixture of bismuth nitrate / acetic anhydride in DCM with a series of substituted anilines under mild reflux. METHODS: Several anilines having both activating and deactivating substituents in the RESULTS: Bi(NO CONCLUSION: Bi(NO