The rising of MXenes not only enriches the two-dimensional material family but also brings more opportunities for diverse functional applications. However, the controllable synthesis of MXenes is still unsatisfied via the common liquid-solid etching route, considering the unsolved problems like safety risk, time cost and easy oxidation. Herein, a facile yet efficient gas-solid (G-S) reaction methodology is devised by using hydrogen fluoride gas derived from fluorinated organics as the MAX etchant toward high-efficiency fabrication of multiple MXenes and their derivatives. The innovative G-S reaction strategy exhibits superb versatility to achieve different gram-level MXenes (V