Expanding functions of the phosphatidylinositol/phosphatidate lipid transporter, PITPNC1 in physiology and in pathology.

• Tác giả: Shamshad Cockcroft
• Ngôn ngữ: eng
• Ký hiệu phân loại: 025.322 *Choice of entry and form of heading
• Thông tin xuất bản: England : Advances in biological regulation , 2025
• Bộ sưu tập: NCBI
• ID: 175559

Tóm tắt

PITPNC1 was the last of the PITPs to be identified and has been characterized as a binding protein for phosphatidylinositol and phosphatidate. In mammals, PITPNC1 is expressed as two splice variants whilst in zebrafish is expressed from two separate genes. The two splice variants have different expression profiles with the long splice variant having a prominent role in the brain. Several physiological functions have been identified including neuronal and metabolic functions. PITPNC1 also plays a significant role in cancer and has been identified as a risk factor in type 2 diabetes. Here, we review our current understanding of PITPNC1 in cell physiology and pathology.