Validation of the NCCN/Yale criteria for the identification of

• Tác giả: Cassidy Carraway, Mar Giner-Calabuig, Rachid Karam, Karl Krahn, Benjamin A Lerner, Xavier Llor, Sarah M Nielsen, Marcy Richardson, Lisa Susswein, Rosa M Xicola
• Ngôn ngữ: eng
• Ký hiệu phân loại: 332.4048 Money
• Thông tin xuất bản: England : Journal of medical genetics , 2025
• Bộ sưu tập: NCBI
• ID: 175858

Tóm tắt

BACKGROUND: Diffuse gastric and lobular breast cancer (LBC) syndrome is an autosomal-dominant syndrome characterised by early-onset diffuse gastric cancer and LBC most often caused by germline pathogenic variants (PVs) in METHODS: We aggregated demographic and clinical data of all RESULTS: Data on 708 probands and their 4318 family members were included in the analysis. In this cohort, the sensitivities for detecting CONCLUSION: In a large cohort of