MR perfusion characteristics of pseudoprogression in brain tumors treated with immunotherapy - a comparative study with chemo-radiation induced pseudoprogression and radiation necrosis.

• Tác giả: Rajnish Bharadwaj, Hongyan Chen, Wenjing Han, Yichuan Hu, Yi Huang, Haihui Jiang, Qiong Liang, Xiang Liu, Stephen M Smith, Denes Szekeres, Guirong Tan, Henry Z Wang, Lijuan Zhong
• Ngôn ngữ: eng
• Ký hiệu phân loại: 636.0885 Animal husbandry
• Thông tin xuất bản: United States : Journal of neuro-oncology , 2025
• Bộ sưu tập: NCBI
• ID: 175922

Tóm tắt

PURPOSE: Pseudoprogression is an atypical imaging pattern of response to immunotherapy in patients with brain tumors. MR perfusion studies in this field are limited. The purpose of our study is to compare the perfusion features between pseudoprogression lesions in malignant gliomas and brain metastases treated with immunotherapy (iPsP) and the pseudoprogression after chemo-radiation therapy and radiation necrosis after radiation treatment (ChR-PsP & RN). METHODS: We retrospectively reviewed 25 iPsP lesions in 16 brain tumor patients and 48 ChR-PsP & RN lesions in 35 patients. The cerebral blood volume (CBV) of MR dynamic susceptibility contrast (DSC) perfusion weighted imaging (PWI) was analyzed, and the mean and maximal values of the ratio of CBV (rCBV RESULTS: The medians of rCBV CONCLUSION: These findings may suggest immunotherapy-induced higher perfusion in the iPsP lesions compared to ChR-PsP & RN lesions in primary and metastatic brain tumors.