In vivo anti-hyperglycemic activity and toxicity evaluation of two bis-coumarin derivative as potential α-glucosidase inhibitors.

• Tác giả: Forough Aghajani, Nematollah Ahangar, Tayebeh Bahrami, Fatemeh Bandarian, Mohammad Mahdavi, Maryam Mohammadi-Khanaposhtani, Ensieh Nasli-Esfahani, Davoud Roostaei, Ehsan Zamani
• Ngôn ngữ: eng
• Thông tin xuất bản: Switzerland : Journal of diabetes and metabolic disorders , 2025
• Bộ sưu tập: NCBI
• ID: 176160

Tóm tắt

OBJECTIVES: The in vivo assay is a key step in the development of a new compound as a drug. In the present work, bis-4-aminocoumarin derivative 3,3'-(p-tolylmethylene)bis(4-amino-2H-chromen-2-one) ( METHODS: The in vivo anti-hyperglycemic effect of RESULTS: The obtained results revealed that both selected compounds, CONCLUSIONS: In summary, in vivo anti-hyperglycemic effects of two synthetic compounds