Sodium nitrite orchestrates macrophage mimicry of tongue squamous carcinoma cells to drive lymphatic metastasis.

• Tác giả: Haoxiang Chen, Wuheng Huang, Weifan Lin, Xiangwan Lu, Hua Wang, Shuyi Yu, Yan Zhang, Junheng Zheng
• Ngôn ngữ: eng
• Ký hiệu phân loại: 549.732 Nitrates
• Thông tin xuất bản: England : British journal of cancer , 2025
• Bộ sưu tập: NCBI
• ID: 176670

Tóm tắt

BACKGROUND: Tongue squamous cell carcinoma (TSCC) is a malignant oral cancer with unclear pathogenesis that shows a tendency for early-stage lymphatic metastasis. This results in a poor prognosis, with a low 5-year survival rate. Dietary sodium nitrite (NaNO METHODS: In vitro and in vivo assays were used to investigate the role of NaNO RESULTS: The data in this study showed that NaNO CONCLUSIONS: Our findings highlight the role of NaNO2 in enabling macrophage mimicry in TSCC cells through the CREB1-CD68 signaling pathway, which promotes lymphatic metastasis. Shedding light on drivers of lymphatic metastasis in TSCC and providing a new perspective on dietary strategies to improve outcomes of patients with TSCC.