Nicotine Metabolism-Related Genetic Polymorphisms Associated with Smoking Cessation in Korean Men: A Candidate Gene Association Study in a Korean Cohort.

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Tác giả: Ja-Eun Choi, Kyung-Won Hong, Ji-Won Lee, Jae-Min Park

Ngôn ngữ: eng

Ký hiệu phân loại: 573.59 *Scales, feathers, horns, related topics

Thông tin xuất bản: Switzerland : Lifestyle genomics , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 176721

 INTRODUCTION: Smoking cessation is influenced by genetic and environmental factors, particularly genetic polymorphisms influencing nicotine metabolism. This study investigated the association between specific nicotine metabolism-related genetic variants and smoking cessation among Korean men. METHODS: A candidate gene association study was performed targeting single nucleotide polymorphisms (SNPs) within nicotine metabolism-related genes. Participants were categorized as never, former, or current smokers. A Genetic Risk Score (GRS) was computed using significant SNPs to evaluate cumulative genetic influence. RESULTS: Six SNPs showed significant association with smoking cessation in a Korean cohort. A higher GRS was associated with increased odds of current smoking compared to former smoking (OR = 1.18, 95% CI: 1.12-1.25, p <
  0.001). CONCLUSION: This study indicates a substantial genetic component in smoking cessation, highlighting the importance of population-specific approaches, and may aid personalized smoking cessation strategies based on genetic predisposition among Koreans.
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