Transcriptomic landscape of hyperthyroidism in mice overexpressing thyroid-Stimulating hormone.

• Tác giả: Toshihito Fujii, Haruka Fujita, Takuro Hakata, Nobuya Inagaki, Sadahito Kimura, Yo Kishimoto, Tomoko Kita, Daisuke Kosugi, Kentaro Okamoto, Yoriko Sakane, Aya Sakurai, Taku Sugawa, Daisuke Taura, Yohei Ueda, Ichiro Yamauchi, Akihiro Yasoda, Akira Yoshizawa
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : iScience , 2025
• Bộ sưu tập: NCBI
• ID: 176795

Tóm tắt

Activation of thyroid-stimulating hormone receptor (TSHR) fundamentally leads to hyperthyroidism. To elucidate TSHR signaling, we conducted transcriptome analyses for hyperthyroid mice that we generated by overexpressing TSH. TSH overexpression drastically changed their thyroid transcriptome. In particular, enrichment analyses identified the cell cycle, phosphatidylinositol 3-kinase/Akt pathway, and Ras-related protein 1 pathway as possibly associated with goiter development. Regarding hyperthyroidism,