BACKGROUND: To compare platelet count (PC), mean platelet volume (MPV), and platelet distribution width (PDW) between women with preeclampsia (PE) and normotensive pregnant women, and evaluate their effectiveness as predictors of PE. RESEARCH DESIGN AND METHODS: This cross-sectional study at Nishtar Hospital, Multan, included 141 women: 74 normotensive and 67 preeclamptic. Data was collected using an automated hematology analyzer and analyzed with SPSS version 26 and ROC curves. RESULTS: Mean age was 27.45 ± 5.18 years for cases and 28.41 ± 5.28 years for controls ( CONCLUSIONS: PDW and MPV are significantly altered in preeclamptic women and can aid in early detection, potentially enhancing management.