In this study, data from 7,440 patients from six Ibero-American countries were analyzed, focusing on men who consulted for erectile dysfunction (ED). Participants were queried about infidelity in their relationships. Results showed a negative correlation between infidelity and the severity of ED, suggesting that the likelihood of infidelity decreases as the severity of ED increases. Additionally, alcohol consumption and age were identified as significant predictors of infidelity, with notable country-specific variations. No significant associations were found between infidelity and other variables such as comorbidities affecting erectile function, sexual activity frequency, or suspected hypogonadism, measured using the AMS questionnaire.