Nanophotonic devices control and manipulate light at the nanometer scale. Applications include biological imaging, integrated photonic circuits, and metamaterials. The design of these devices requires the accurate modeling of light-matter interactions at the nanoscale and the optimization of multiple design parameters, both of which can be computationally demanding and time intensive. Further, fabrication of these devices demands a high level of accuracy, resolution, and throughput while ideally being able to incorporate multiple materials in complex geometries. To address these considerations in the realization of nanophotonic devices, recent work within our lab has pursued the efficient and accurate modeling of nanoparticles and the assembly of complex 3D micro- and nanostructures using optical tweezers. This Feature Article review highlights these developments as well as related efforts by others in computation and fabrication methods related to nanophotonic devices and metamaterials.