Study of antiplasmodial activity, toxicity, pharmacokinetic profiles of n-methyl-isatin (CH

• Tác giả: Valter Ferreira de Andrade-Neto, Brenna Marceliane de Melo Marcelino, Kardilandia Mendes de Oliveira, Gabriela Tafaela Dias, Margareth de Fátima Formiga Melo Diniz, Caliandra Maria Bezerra Luna Lima, Claudio Gabriel Lima-Júnior, Cinthia Rodrigues Melo, Abrahão Alves de Oliveira Filho, Igor Gabriel da Silva Ramalho, Giciane Carvalho Vieira
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Experimental parasitology , 2025
• Bộ sưu tập: NCBI
• ID: 177616

Tóm tắt

One of the main factors that have made it difficult to control malaria is the large number of parasites that are resistant to the usual antimalarial drugs. Therefore, the development of new drugs that are more effective and with low toxicity for humans is necessary. In this work, we evaluated the adduct 2-(3-hydroxy-1-methyl-2-oxoindolin-3-yl)acrylonitrile, also called CH