Catecholamine synthesis and secretion by adrenal chromaffin cells are reduced in deer mice native to high altitude.

• Tác giả: Nicole A Pranckevicius, Aedan J Rourke, Ranim Saleem, Angela L Scott, Graham R Scott, Oliver H Wearing
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : American journal of physiology. Regulatory, integrative and comparative physiology , 2025
• Bộ sưu tập: NCBI
• ID: 177632

Tóm tắt

Hypoxia at high altitude can constrain aerobic metabolism and elicit physiological responses that are detrimental to health and fitness. Responses of the sympathoadrenal system are vital for coping with acute hypoxia but can become maladaptive with prolonged activation in chronic hypoxia. We examined how adrenal function is altered in high-altitude populations of deer mice (