ROS-responsive poly(β-amino ester) nanoparticles enable targeted delivery of mRNA vaccine to splenic antigen-presenting cells.

• Tác giả: Baihua Chen, Jinjin Chen, Meng Jiang, Min Qiu, Yingseng Tang, Lingjian Yan, Ling Zeng, Zixi Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 515.7242 Functional analysis
• Thông tin xuất bản: England : Chemical communications (Cambridge, England) , 2025
• Bộ sưu tập: NCBI
• ID: 177711

Tóm tắt

Intravenous mRNA vaccines show promise for stimulating immune cells but face challenges in targeting APCs due to high liver accumulation. To address this, we developed ROS-responsive PBAE nanoparticles, 93-TKA10-19, designed to target splenic APCs, enhance mRNA expression, and induce a Th1-skewed immune response, advancing mRNA vaccine efficacy.