Endothelial dysfunction in middle-aged and older men with low testosterone is associated with elevated circulating endothelin-1.

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Tác giả: Matthew C Babcock, Lyndsey E DuBose, Kerry L Hildreth, Wendy M Kohrt, Kerrie L Moreau, Brian L Stauffer, Megan M Wenner

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: United States : American journal of physiology. Regulatory, integrative and comparative physiology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 177717

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Low testosterone in middle-aged/older men contributes to accelerated vascular aging, including endothelial dysfunction. However, the mechanisms by which low testosterone affects endothelial dysfunction are not well understood. We sought to determine whether higher endothelin-1 (ET-1) levels are associated with reduced brachial artery flow-mediated dilation (FMD) in middle-aged/older men with low testosterone. Plasma ET-1 was quantified in 60 men categorized as young (

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